Sesquiterpenes, lignans and other constituents from Saussurea macrota

Min Yang, Chun Ming Wang, Qi Zhang, Yi Feng Han, Zhong Jian Jia

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

Original languageEnglish (US)
Pages (from-to)972-976
Number of pages5
JournalPharmazie
Volume59
Issue number12
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Pharmaceutical Science

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