Sesquiterpenes, lignans and other constituents from Saussurea macrota

Min Yang; Chun Ming Wang; Qi Zhang; Yi Feng Han; Zhong Jian Jia

Sesquiterpenes, lignans and other constituents from Saussurea macrota

Min Yang, Chun Ming Wang, Qi Zhang, Yi Feng Han, Zhong Jian Jia

Research output: Contribution to journal › Article › peer-review

Abstract

From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

Original language	English (US)
Pages (from-to)	972-976
Number of pages	5
Journal	Pharmazie
Volume	59
Issue number	12
State	Published - Dec 2004

ASJC Scopus subject areas

Pharmaceutical Science

Cite this

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title = "Sesquiterpenes, lignans and other constituents from Saussurea macrota",

abstract = "From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.",

author = "Min Yang and Wang, {Chun Ming} and Qi Zhang and Han, {Yi Feng} and Jia, {Zhong Jian}",

year = "2004",

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language = "English (US)",

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T1 - Sesquiterpenes, lignans and other constituents from Saussurea macrota

AU - Yang, Min

AU - Wang, Chun Ming

AU - Zhang, Qi

AU - Han, Yi Feng

AU - Jia, Zhong Jian

PY - 2004/12

Y1 - 2004/12

N2 - From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

AB - From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3α-hydroxy- 11αH-guaia-4(15),10(14)-diene-12,6α-olide (1) and 7′-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.

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ER -

Sesquiterpenes, lignans and other constituents from Saussurea macrota

Abstract

ASJC Scopus subject areas

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