Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis

Xia Hong, Shan Jiang, Nancy Marmolejo, Ramya Vangipuram, Elmira Ramos-Rojas, Yulin Yuan, Zuan Tao Lin, Yaxi Li, Jingyi Qiu, Yikun Xing, Christopher Haley, Stephen K. Tyring, Tianfu Wu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To discover novel biomarkers of psoriasis, a target-specific antibody array screening of serum samples from psoriasis patients was initially performed. The results revealed that vascular endothelial growth factor receptor 3 (VEGFR-3) was significantly elevated in the sera of psoriasis patients, compared to healthy controls. Next, ELISA validation studies in a larger cohort of psoriasis patients (N = 73) were conducted, which confirmed that serum VEGFR-3 was indeed significantly increased in patients with psoriasis compared to healthy controls (P < 0.001). Furthermore, receiver operating characteristic curve analysis demonstrated that serum VEGFR-3 exhibited potential in distinguishing healthy controls from psoriasis patients: area under the curve = 0.85, P < 0.001. In addition, serum levels of VEGFR-3 were correlated with Psoriasis Area Severity Index scores (R = 0.32, P = 0.008) in psoriasis patients. Interestingly, serum VEGFR-3 levels were significantly elevated in psoriatic arthritis compared to non-psoriatic arthritis (P = 0.026). A pilot longitudinal study demonstrated that serum levels of VEGFR-3 could reflect disease progression in psoriasis. Collectively, serum VEGFR-3 may have a clinical value in monitoring disease activity of psoriasis.

Original languageEnglish (US)
JournalExperimental Dermatology
DOIs
StateAccepted/In press - 2018

Keywords

  • Biomarker
  • Psoriasis
  • Vascular endothelial growth factor receptor 3

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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