TY - JOUR
T1 - Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease
AU - Hegde, Muralidhar L.
AU - Shanmugavelu, Ponnuswamy
AU - Vengamma, Bhuma
AU - Rao, T. S Sathyanarayana
AU - Menon, Rani B.
AU - Rao, Ranganath V.
AU - Rao, K. S Jagannatha
N1 - Funding Information:
The authors thank Dr. V. Prakash, Director, CFTRI, Shri B. Bhattacharjee, Director, BARC, Mumbai, Shri. T.K. Bera, Project Manager, BARC for their encouragement, as well as Dr. Luigi Zecca, CNR-Institute, Italy for his suggestions. We thank the clinicians and nurses at the SVIMS and JSS Hospitals for their assistance in collecting the blood samples. We also thank the CSIR-CNR project on toxicity of metals in human brain for financial support. MLH thanks the Council of Scientific and Industrial Research, New Delhi for his Senior Research Fellowship.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - Trace elements have been postulated to play a role in Parkinson's disease (PD). In order to elucidate whether changes in the serum levels of trace elements reflect the progression of PD, we assessed serum levels of 12 elements (Na, K, Fe, Al, Cu, Zn, Ca, Mg, Mn, Si, P and S) in early PD, severe PD and normal subjects, using inductively coupled plasma atomic emission spectrometry. The concentrations in μmol/ml, the relative mole percentage distribution and inter-element relations were computed. Statistical analysis of these data showed a definite pattern of variation among certain elements in early and severe PD compared to controls. In both early and severe PD serum, Al and S concentrations were significantly decreased (p<0.05) compared to the controls. Fe (p<0.01) and Zn (p<0.05) concentrations were significantly lower in severe PD, while K, Mg, Cu (p<0.01) and P (p<0.05) concentrations were higher in early and severe PD compared to the controls. The data revealed an imbalance in the inter-element relations in both early and severe PD serum compared to controls, as shown by the direct and inverse correlations. These results suggest a disturbance in the element homeostasis during the progression of PD.
AB - Trace elements have been postulated to play a role in Parkinson's disease (PD). In order to elucidate whether changes in the serum levels of trace elements reflect the progression of PD, we assessed serum levels of 12 elements (Na, K, Fe, Al, Cu, Zn, Ca, Mg, Mn, Si, P and S) in early PD, severe PD and normal subjects, using inductively coupled plasma atomic emission spectrometry. The concentrations in μmol/ml, the relative mole percentage distribution and inter-element relations were computed. Statistical analysis of these data showed a definite pattern of variation among certain elements in early and severe PD compared to controls. In both early and severe PD serum, Al and S concentrations were significantly decreased (p<0.05) compared to the controls. Fe (p<0.01) and Zn (p<0.05) concentrations were significantly lower in severe PD, while K, Mg, Cu (p<0.01) and P (p<0.05) concentrations were higher in early and severe PD compared to the controls. The data revealed an imbalance in the inter-element relations in both early and severe PD serum compared to controls, as shown by the direct and inverse correlations. These results suggest a disturbance in the element homeostasis during the progression of PD.
KW - Early PD
KW - Element homeostasis
KW - Inter-element relation
KW - Parkinson's disease
KW - Serum
KW - Severe PD
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U2 - 10.1016/j.jtemb.2004.09.003
DO - 10.1016/j.jtemb.2004.09.003
M3 - Article
C2 - 15646263
AN - SCOPUS:10844247373
SN - 0946-672X
VL - 18
SP - 163
EP - 171
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
IS - 2
ER -