Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system - The concept of tissue specificity

S. M. Moghimi, H. M. Patel

Research output: Contribution to journalReview article

187 Scopus citations

Abstract

The mechanisms responsible for the clearance and recognition of intravenously injected liposomes by phagocytic cells of the reticuloendothelial system are presently not well understood. Here, we address a multiplicity of physicochemical and physiopathological factors which influence the clearance kinetics and tissue distribution of liposomes administered into the circulation. Emphasis is particularly drawn towards the concept of liposome-blood protein interaction and its role in liposome recognition by various phagocytes of the reticuloendothelial system.

Original languageEnglish (US)
Pages (from-to)45-60
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume32
Issue number1-2
DOIs
StatePublished - Jun 8 1998

Keywords

  • Liposome
  • Liver
  • Macrophage
  • Opsonin
  • Opsono- phagocytosis
  • Reticuloendothelial system
  • Spleen

ASJC Scopus subject areas

  • Pharmaceutical Science

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