Serum globulin in myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors

Richard R. Almon; Clifford G. Andrew; Stanley H. Appel

doi:10.1126/science.186.4158.55

Serum globulin in myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors

Richard R. Almon, Clifford G. Andrew, Stanley H. Appel

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296 Scopus citations

Abstract

Serum factors that inhibit the binding of ¹²⁵I labeled α bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.

Original language	English (US)
Pages (from-to)	55-57
Number of pages	3
Journal	Science
Volume	186
Issue number	4158
DOIs	https://doi.org/10.1126/science.186.4158.55
State	Published - 1974

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abstract = "Serum factors that inhibit the binding of 125I labeled α bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.",

author = "Almon, {Richard R.} and Andrew, {Clifford G.} and Appel, {Stanley H.}",

year = "1974",

doi = "10.1126/science.186.4158.55",

language = "English (US)",

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T1 - Serum globulin in myasthenia gravis

T2 - Inhibition of α-bungarotoxin binding to acetylcholine receptors

AU - Almon, Richard R.

AU - Andrew, Clifford G.

AU - Appel, Stanley H.

PY - 1974

Y1 - 1974

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AB - Serum factors that inhibit the binding of 125I labeled α bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.

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JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

SN - 0036-8075

IS - 4158

ER -

Serum globulin in myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors

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