Serum biomarkers for personalization of nanotherapeutics-based therapy in different tumor and organ microenvironments

Kenji Yokoi, Tomonori Tanei, Biana Godin, Anne L. van de Ven, Masaki Hanibuchi, Aika Matsunoki, Jenolyn Alexander, Mauro Ferrari

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Enhanced permeation and retention (EPR) effect, the mechanism by which nanotherapeutics accumulate in tumors, varies in patients based on differences in the tumor and organ microenvironment. Surrogate biomarkers for the EPR effect will aid in selecting patients who will accumulate higher amounts of nanotherapeutics and show better therapeutic efficacy. Our data suggest that the differences in the vascular permeability and pegylated liposomal doxorubicin (PLD) accumulation are tumor type as well as organ-specific and significantly correlated with the relative ratio of MMP-9 to TIMP-1 in the circulation, supporting development of these molecules as biomarkers for the personalization of nanoparticle-based therapy.

Original languageEnglish (US)
Pages (from-to)48-55
Number of pages8
JournalCancer Letters
Volume345
Issue number1
DOIs
StatePublished - Apr 1 2014

Keywords

  • Biomarker
  • EPR effect
  • Nanotherapeutics
  • PLD
  • Transport oncophysics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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