Serum and lymphocyte, aluminum and nickel in chronic renal failure

Michael R. Wills, Catherine S. Brown, Roger L. Bertholf, Richard Ross, John Savory

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


In the past decade, aluminum has been recognized as a toxic metal in patients with chronic renal failure. It is, however, possible that other trace metals, such as nickel, may also have toxic actions in these patients. The plasma concentration of a metal, such as aluminum or nickel, may not provide a valid index of either tissue content or total body burden. In the study reported here, the aluminum and nickel content of lymphocytes was measured and compared with plasma concentrations in normal controls and patients with chronic renal failure. The findings suggest that lymphocytes may be of value as a nucleated 'tissue' for the assessment of trace metal status.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalClinica Chimica Acta
Issue number2
StatePublished - Jan 30 1985


  • Aluminum
  • Lymphocyte
  • Nickel
  • Renal failure
  • Serum

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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