SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers

Loku Gunawardhana; Katerina Kourentzi; Adheesha N. Danthanarayana; Jakoah Brgoch; Xiaonan Shan; Richard C. Willson; Wei Chuan Shih

doi:10.1109/JSTQE.2021.3062548

SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers

Loku Gunawardhana, Katerina Kourentzi, Adheesha N. Danthanarayana, Jakoah Brgoch, Xiaonan Shan, Richard C. Willson, Wei Chuan Shih

Houston Methodist

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.

Original language	English (US)
Article number	9366787
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	27
Issue number	5
DOIs	https://doi.org/10.1109/JSTQE.2021.3062548
State	Published - Sep 1 2021

Keywords

Laser biomedical applications
lateral flow assay (LFA)
nanotechnology
plasmons
surface enhanced raman scattering (SERS)

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JSTQE.2021.3062548

Cite this

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title = "SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers",

abstract = "The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.",

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AU - Gunawardhana, Loku

AU - Kourentzi, Katerina

AU - Danthanarayana, Adheesha N.

AU - Brgoch, Jakoah

AU - Shan, Xiaonan

AU - Willson, Richard C.

AU - Shih, Wei Chuan

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N2 - The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.

AB - The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.

KW - Laser biomedical applications

KW - lateral flow assay (LFA)

KW - nanotechnology

KW - plasmons

KW - surface enhanced raman scattering (SERS)

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SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers

Abstract

Keywords

ASJC Scopus subject areas

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