SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers

Loku Gunawardhana, Katerina Kourentzi, Adheesha N. Danthanarayana, Jakoah Brgoch, Xiaonan Shan, Richard C. Willson, Wei Chuan Shih

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.

Original languageEnglish (US)
Article number9366787
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume27
Issue number5
DOIs
StatePublished - Sep 1 2021

Keywords

  • Laser biomedical applications
  • lateral flow assay (LFA)
  • nanotechnology
  • plasmons
  • surface enhanced raman scattering (SERS)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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