SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers

Loku Gunawardhana, Katerina Kourentzi, Adheesha N. Danthanarayana, Jakoah Brgoch, Xiaonan Shan, Richard C. Willson, Wei Chuan Shih

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.

Original languageEnglish (US)
Article number9366787
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number5
StatePublished - Sep 1 2021


  • Laser biomedical applications
  • lateral flow assay (LFA)
  • nanotechnology
  • plasmons
  • surface enhanced raman scattering (SERS)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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