Serotonin and dopamine play complementary roles in gambling to recover losses

Daniel Campbell-Meiklejohn, Judi Wakeley, Vanessa Herbert, Jennifer Cook, Paolo Scollo, Manaan Kar Ray, Sudhakar Selvaraj, Richard E. Passingham, Phillip Cowen, Robert D. Rogers

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Continued gambling to recover lossesloss chasingis a prominent feature of social and pathological gambling. However, little is known about the neuromodulators that influence this behavior. In three separate experiments, we investigated the role of serotonin activity, D 2 /D 3 receptor activity, and beta-adrenoceptor activity on the loss chasing of age and IQ-matched healthy adults randomized to treatment or an appropriate control/placebo. In Experiment 1, participants consumed amino-acid drinks that did or did not contain the serotonin precursor, tryptophan. In Experiment 2, participants received a single 176 g dose of the D 2 /D 3 receptor agonist, pramipexole, or placebo. In Experiment 3, participants received a single 80 mg dose of the beta-adrenoceptor blocker, propranolol, or placebo. Following treatment, participants completed a computerized loss-chasing game. Mood and heart rate were measured at baseline and following treatment. Tryptophan depletion significantly reduced the number of decisions made to chase losses, and the number of consecutive decisions to chase, in the absence of marked changes in mood. By contrast, pramipexole significantly increased the value of losses chased and diminished the value of losses surrendered. Propranolol markedly reduced heart rate, but produced no significant changes in loss-chasing behavior. Loss chasing can be thought of as an aversively motivated escape behavior controlled, in part, by the marginal value of continued gambling relative to the value of already accumulated losses. Serotonin and dopamine appear to play dissociable roles in the tendency of individuals to gamble to recover, or to seek to escape from, previous losses. Serotonergic activity seems to promote the availability of loss chasing as a behavioral option, whereas D 2 /D 3 receptor activity produces complex changes in the value of losses judged worth chasing. Sympathetic arousal, at least as mediated by beta-adrenoceptors, does not play a major role in laboratory-based loss-chasing choices.

Original languageEnglish (US)
Pages (from-to)402-410
Number of pages9
Issue number2
StatePublished - Jan 2011


  • dopamine
  • gambling
  • loss chasing
  • persistence
  • serotonin
  • value

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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