Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

L. Bueno, F. De Ponti, M. Fried, G. A. Kullak-Ublick, M. A. Kwiatek, D. Pohl, E. M.M. Quigley, J. Tack, N. J. Talley

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

Original languageEnglish (US)
Pages (from-to)89-119
Number of pages31
JournalNeurogastroenterology and Motility
Issue numberSUPPL.1
StatePublished - Jan 2007


  • Abdominal pain
  • Drugs
  • Enteric flora
  • GI disorders
  • Gut
  • Sensitivity
  • Serotonin

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)


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