Serotonergic and non-serotonergic targets in the pharmacotherapy of visceral hypersensitivity

L. Bueno, F. De Ponti, M. Fried, G. A. Kullak-Ublick, M. A. Kwiatek, D. Pohl, Eamonn Martin Quigley, J. Tack, N. J. Talley

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.

Original languageEnglish (US)
Pages (from-to)89-119
Number of pages31
JournalNeurogastroenterology and Motility
Volume19
Issue numberSUPPL.1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Abdominal pain
  • Drugs
  • Enteric flora
  • GI disorders
  • Gut
  • Sensitivity
  • Serotonin

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

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