Abstract
Resting tomographic myocardial perfusion images using technetium-99m-hexakis-2-methylpropyl-isonitrile (Tc-Sestamibi) were obtained in 25 patients during their first myocardial infarction. Tc-Sestamibi was injected intravenously before acute reperfusion therapy, and repeated twice, at 18-48 hr, and at 6 to 14 days. Reperfusion was successful in 19 patients. In the patients with successful reperfusion, there was a mean decrease in the amount of hypoperfused myocardium between the initial and second studies (-9% ± 12%, p = 0.004) and a further decrease between the second and final studies (-10% ± 12%, p = 0.002). Nine of these 19 patients (47%) had evidence of significant improvement at the time of the second study. In six patients, significant improvement was not evident until the final study. Although tomographic imaging with Tc-Sestamibi following reperfusion therapy may show improvement in perfusion at 18-48 hr, the full extent of improvement is usually not evident until later.
Original language | English (US) |
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Pages (from-to) | 1269-1275 |
Number of pages | 7 |
Journal | Journal of Nuclear Medicine |
Volume | 31 |
Issue number | 8 |
State | Published - Jan 1 1990 |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging