Abstract
Purpose: To analyze sequential chorioretinal changes in presumed ocular histoplasmosis syndrome (POHS) using volumetric spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 28 treatment-naive eyes of 20 POHS patients were characterized as: no choroidal neovascular membrane (CNVM) at initial SD-OCT but CNVM development during follow-up (primary group); CNVM at initial SD-OCT (progressive group); and contralateral asymptomatic eyes (control group). Results: The primary group (4/28 eyes) initially demonstrated external limiting membrane (ELM), ellipsoid zone and retinal pigment epithelium (RPE)/Bruch’s disruption in 100%, and pigment epithelial detachment (PED) in 75% of eyes. CNVM developed in 100% of eyes during follow-up. Progressive group (8/28 eyes) showed CNVM in 100% of eyes. Control group (16/28 eyes) showed ELM disruption in two and PED in three additional eyes on follow-up from initial analysis. Conclusions: SD-OCT is a useful tool to sequentially follow eyes with POHS for subtle chorioretinal changes that may suggest impending CNVM development, and thus benefit from closer clinical monitoring.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 545-553 |
| Number of pages | 9 |
| Journal | Ocular Immunology and Inflammation |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 4 2017 |
Keywords
- Choroidal neovascular membrane
- histo spots
- pigment epithelial detachment
- presumed ocular histoplasmosis syndrome
- spectral-domain optical coherence tomography
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology
Fingerprint
Dive into the research topics of 'Sequential Chorioretinal Changes in Presumed Ocular Histoplasmosis Syndrome Analyzed Using Spectral Domain Optical Coherence Tomography'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS