@article{fe55f6ec550d46c1b9cb7fddf28877be,
title = "Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain",
abstract = "Senile plaques found in the brains of patients with Alzheimer's disease (AD) are surrounded by clusters of reactive microglia. Isolated human microglia placed in contact with plaques in vitro are activated to release a factor which is toxic to neurons. This same neurotoxin is found in AD brain tissue and causes damage to pyramidal neurons in vivo when infused into rat hippocampus. Highest concentrations of the neurotoxin are in those brain structures most burdened by reactive microglia, suggesting that plaque-activated cells contribute to the neuronal damage and impaired cognition seen in patients with Alzheimer's dementia.",
author = "Dana Giulian and Haverkamp, {Lanny J.} and Jun Li and Karshin, {William L.} and Jenny Yu and Donald Tom and Xia Li and Kirkpatrick, {Joel B.}",
note = "Funding Information: Acknowledgements- This work was supportedb y grant NS25637 from the NIH and by funds from the Alzheimer{\textquoteright}s Association, the Vivian Smith Foundation, the Methodist Hospital Foundationa nd the Alzheimer Disease Research Center at Baylor College of Medicine. We thank C. Keenan,B .S., B. Leara, B.S., Ming-Hiu Jiang M.D. and D. Mansouri, B.S. for technical assistance. We also thank memberso f the Alzheimer Disease Reseach Center for their thoughtful suggestions. This research was made possible by a rapid autopsy program at The Methodist Hospital, Houston, Texas, with the cooperation of D. Armstrong, M.D, C. Goodman, M.D. and H. Vogel, M.D. and the assistanceo f D. Marks and R. Cortez of the Departmenot f Pathology,B aylor College of Medicine.",
year = "1995",
month = jul,
doi = "10.1016/0197-0186(95)00067-I",
language = "English (US)",
volume = "27",
pages = "119--137",
journal = "Neurochemistry International",
issn = "0197-0186",
publisher = "Elsevier Ltd",
number = "1",
}