Semiconductor light-emitting devices with in-built bioreaction chambers

H. D. Summers; D. R. Matthews; R. J. Errington; K. L. Njoh; P. J. Smith; A. D. Goater; J. P H Burt; N. H. Rizvi; A. Menachery; D. J. Morris

doi:10.1117/12.700411

Semiconductor light-emitting devices with in-built bioreaction chambers

H. D. Summers, D. R. Matthews, R. J. Errington, K. L. Njoh, P. J. Smith, A. D. Goater, J. P H Burt, N. H. Rizvi, A. Menachery, D. J. Morris

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

We demonstrate complete integration of a fluorescence-based assay in that the analyte well is also an optical emitter. Laser machining is used to create 'active micro-wells' within semiconductor light emitting diode and laser structures. These are then used to optically excite fluorescently-labelled beads in solution within the well. The results show efficient illumination on a par with traditional lamp-based excitation. This technology therefore provides active micro-well plates with completely localized excitation, confined to the analysis well, that can be engineered via the micro-well geometry. The micro-wells have also been machined within the cavity of lasing semiconductor structures and coherent emission maintained. Thus lasing multi-well plates are also realizable.

Original language	English (US)
Title of host publication	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
DOIs	https://doi.org/10.1117/12.700411
State	Published - 2007
Event	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V - San Jose, CA, United States Duration: Jan 22 2007 → Jan 24 2007

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6441
ISSN (Print)	1605-7422

Other

Other	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
Country/Territory	United States
City	San Jose, CA
Period	1/22/07 → 1/24/07

Keywords

Fluorescence
Optoelectronics
Semiconductor lasers

ASJC Scopus subject areas

General Engineering

Access to Document

10.1117/12.700411

Cite this

Summers, H. D., Matthews, D. R., Errington, R. J., Njoh, K. L., Smith, P. J., Goater, A. D., Burt, J. P. H., Rizvi, N. H., Menachery, A., & Morris, D. J. (2007). Semiconductor light-emitting devices with in-built bioreaction chambers. In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V Article 64410Y (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6441). https://doi.org/10.1117/12.700411

Semiconductor light-emitting devices with in-built bioreaction chambers. / Summers, H. D.; Matthews, D. R.; Errington, R. J. et al.
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V. 2007. 64410Y (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6441).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Summers, HD, Matthews, DR, Errington, RJ, Njoh, KL, Smith, PJ, Goater, AD, Burt, JPH, Rizvi, NH, Menachery, A & Morris, DJ 2007, Semiconductor light-emitting devices with in-built bioreaction chambers. in Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V., 64410Y, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, San Jose, CA, United States, 1/22/07. https://doi.org/10.1117/12.700411

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title = "Semiconductor light-emitting devices with in-built bioreaction chambers",

abstract = "We demonstrate complete integration of a fluorescence-based assay in that the analyte well is also an optical emitter. Laser machining is used to create 'active micro-wells' within semiconductor light emitting diode and laser structures. These are then used to optically excite fluorescently-labelled beads in solution within the well. The results show efficient illumination on a par with traditional lamp-based excitation. This technology therefore provides active micro-well plates with completely localized excitation, confined to the analysis well, that can be engineered via the micro-well geometry. The micro-wells have also been machined within the cavity of lasing semiconductor structures and coherent emission maintained. Thus lasing multi-well plates are also realizable.",

keywords = "Fluorescence, Optoelectronics, Semiconductor lasers",

author = "Summers, \{H. D.\} and Matthews, \{D. R.\} and Errington, \{R. J.\} and Njoh, \{K. L.\} and Smith, \{P. J.\} and Goater, \{A. D.\} and Burt, \{J. P H\} and Rizvi, \{N. H.\} and A. Menachery and Morris, \{D. J.\}",

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AU - Summers, H. D.

AU - Matthews, D. R.

AU - Errington, R. J.

AU - Njoh, K. L.

AU - Smith, P. J.

AU - Goater, A. D.

AU - Burt, J. P H

AU - Rizvi, N. H.

AU - Menachery, A.

AU - Morris, D. J.

PY - 2007

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N2 - We demonstrate complete integration of a fluorescence-based assay in that the analyte well is also an optical emitter. Laser machining is used to create 'active micro-wells' within semiconductor light emitting diode and laser structures. These are then used to optically excite fluorescently-labelled beads in solution within the well. The results show efficient illumination on a par with traditional lamp-based excitation. This technology therefore provides active micro-well plates with completely localized excitation, confined to the analysis well, that can be engineered via the micro-well geometry. The micro-wells have also been machined within the cavity of lasing semiconductor structures and coherent emission maintained. Thus lasing multi-well plates are also realizable.

AB - We demonstrate complete integration of a fluorescence-based assay in that the analyte well is also an optical emitter. Laser machining is used to create 'active micro-wells' within semiconductor light emitting diode and laser structures. These are then used to optically excite fluorescently-labelled beads in solution within the well. The results show efficient illumination on a par with traditional lamp-based excitation. This technology therefore provides active micro-well plates with completely localized excitation, confined to the analysis well, that can be engineered via the micro-well geometry. The micro-wells have also been machined within the cavity of lasing semiconductor structures and coherent emission maintained. Thus lasing multi-well plates are also realizable.

KW - Fluorescence

KW - Optoelectronics

KW - Semiconductor lasers

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V

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Y2 - 22 January 2007 through 24 January 2007

ER -

Semiconductor light-emitting devices with in-built bioreaction chambers

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Keywords

ASJC Scopus subject areas

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