Semiconductor light-emitting devices with in-built bioreaction chambers

H. D. Summers, D. R. Matthews, R. J. Errington, K. L. Njoh, P. J. Smith, A. D. Goater, J. P H Burt, N. H. Rizvi, A. Menachery, D. J. Morris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We demonstrate complete integration of a fluorescence-based assay in that the analyte well is also an optical emitter. Laser machining is used to create 'active micro-wells' within semiconductor light emitting diode and laser structures. These are then used to optically excite fluorescently-labelled beads in solution within the well. The results show efficient illumination on a par with traditional lamp-based excitation. This technology therefore provides active micro-well plates with completely localized excitation, confined to the analysis well, that can be engineered via the micro-well geometry. The micro-wells have also been machined within the cavity of lasing semiconductor structures and coherent emission maintained. Thus lasing multi-well plates are also realizable.

Original languageEnglish (US)
Title of host publicationImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
DOIs
StatePublished - 2007
EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V - San Jose, CA, United States
Duration: Jan 22 2007Jan 24 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6441
ISSN (Print)1605-7422

Other

OtherImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V
CountryUnited States
CitySan Jose, CA
Period1/22/071/24/07

Keywords

  • Fluorescence
  • Optoelectronics
  • Semiconductor lasers

ASJC Scopus subject areas

  • Engineering(all)

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