Semi-artificial fluorescent molecular machine for DMA damage detection

Vladimir V. Didenko; Candace L. Minchew; Stewart Shuman; David S. Baskin

doi:10.1021/nl048357e

Semi-artificial fluorescent molecular machine for DMA damage detection

Vladimir V. Didenko, Candace L. Minchew, Stewart Shuman, David S. Baskin

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.

Original language	English (US)
Pages (from-to)	2461-2466
Number of pages	6
Journal	Nano Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/nl048357e
State	Published - Dec 2004

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl048357e

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abstract = "The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.",

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AU - Minchew, Candace L.

AU - Shuman, Stewart

AU - Baskin, David S.

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AB - The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.

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Semi-artificial fluorescent molecular machine for DMA damage detection

Abstract

ASJC Scopus subject areas

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