Semi-artificial fluorescent molecular machine for DMA damage detection

Vladimir V. Didenko, Candace L. Minchew, Stewart Shuman, David S. Baskin

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.

Original languageEnglish (US)
Pages (from-to)2461-2466
Number of pages6
JournalNano Letters
Volume4
Issue number12
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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