Self-powered microfluidic chips for multiplexed protein assays from whole blood

Lidong Qin; Ophir Vermesh; Qihui Shi; James R. Heath

doi:10.1039/b821247c

Self-powered microfluidic chips for multiplexed protein assays from whole blood

Lidong Qin, Ophir Vermesh, Qihui Shi, James R. Heath

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.

Original language	English (US)
Pages (from-to)	2016-2020
Number of pages	5
Journal	Lab on a Chip
Volume	9
Issue number	14
DOIs	https://doi.org/10.1039/b821247c
State	Published - Jan 1 2009

ASJC Scopus subject areas

Bioengineering
Biochemistry
General Chemistry
Biomedical Engineering

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10.1039/b821247c

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Self-powered microfluidic chips for multiplexed protein assays from whole blood

Abstract

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