Self-assembled amphiphilic polyhedral oligosilsesquioxane (POSS) grafted poly(vinyl alcohol) (PVA) nanoparticles

Faheem A. Sheikh; Nasser A.M. Barakat; Byoung Suhk Kim; Santosh Aryal; Myung Seob Khil; Hak Yong Kim

doi:10.1016/j.msec.2008.07.029

Self-assembled amphiphilic polyhedral oligosilsesquioxane (POSS) grafted poly(vinyl alcohol) (PVA) nanoparticles

Faheem A. Sheikh, Nasser A.M. Barakat, Byoung Suhk Kim, Santosh Aryal, Myung Seob Khil, Hak Yong Kim

Houston Methodist

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

In the present study, spherical nanoparticles (NPs) containing polyhedral oligosilsesquioxane (POSS) as an inner hydrophobic core and poly(vinyl alcohol) PVA as a hydrophilic outer shell were prepared by dialysis approach. Preparation of amphiphilic POSS-grafted-PVA co-polymer was characterized by ¹H NMR and FT-IR. The results indicated urethane linkage between monoisocyanate group of POSS macromer and the hydroxyl groups of PVA. The dynamic light scattering (DLS) and electrophoretic light scattering (ELS) of the NPs revealed that they have an average hydrodynamic diameter and negative zeta (ζ)-potential of 215 nm and - 161 mV, respectively. Atomic force microscopy (AFM) and bio-transmission electron microscope (BIO-TEM) have shown unagglomerated NPs within a diameter range of 60-90 nm. The prepared NPs were investigated to improve the control release of anticancer drug; paclitaxel as a model drug. Due to drug loading, the hydrodynamic diameter and negative zeta (ζ)-potential have changed to 325 nm and - 14 mV, respectively. In addition, in-vitro drug release experiments were conducted; the obtained results explicated continuous release for over 40 days. However, in case of using pure drug only, the drug completely released within 1 h.

Original language	English (US)
Pages (from-to)	869-876
Number of pages	8
Journal	Materials Science and Engineering C
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.msec.2008.07.029
State	Published - Apr 30 2009

Keywords

Amphiphilic
Dialysis
Drug release
Nanoparticles
Paclitaxel
Self-assembly

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanical Engineering
Mechanics of Materials

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10.1016/j.msec.2008.07.029

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title = "Self-assembled amphiphilic polyhedral oligosilsesquioxane (POSS) grafted poly(vinyl alcohol) (PVA) nanoparticles",

abstract = "In the present study, spherical nanoparticles (NPs) containing polyhedral oligosilsesquioxane (POSS) as an inner hydrophobic core and poly(vinyl alcohol) PVA as a hydrophilic outer shell were prepared by dialysis approach. Preparation of amphiphilic POSS-grafted-PVA co-polymer was characterized by 1H NMR and FT-IR. The results indicated urethane linkage between monoisocyanate group of POSS macromer and the hydroxyl groups of PVA. The dynamic light scattering (DLS) and electrophoretic light scattering (ELS) of the NPs revealed that they have an average hydrodynamic diameter and negative zeta (ζ)-potential of 215 nm and - 161 mV, respectively. Atomic force microscopy (AFM) and bio-transmission electron microscope (BIO-TEM) have shown unagglomerated NPs within a diameter range of 60-90 nm. The prepared NPs were investigated to improve the control release of anticancer drug; paclitaxel as a model drug. Due to drug loading, the hydrodynamic diameter and negative zeta (ζ)-potential have changed to 325 nm and - 14 mV, respectively. In addition, in-vitro drug release experiments were conducted; the obtained results explicated continuous release for over 40 days. However, in case of using pure drug only, the drug completely released within 1 h.",

keywords = "Amphiphilic, Dialysis, Drug release, Nanoparticles, Paclitaxel, Self-assembly",

author = "Sheikh, {Faheem A.} and Barakat, {Nasser A.M.} and Kim, {Byoung Suhk} and Santosh Aryal and Khil, {Myung Seob} and Kim, {Hak Yong}",

note = "Funding Information: This work was supported by Korean Research Foundation Grant founded by Korean Government (MOEHRD) (The Center for Health Care Technology, Chonbuk National University, Jeonju 561-756 Republic of Korea). Author is thankful to Mr. Jong Bae Park of KBSI, Jeonju branch for utilizing his skill to do AFM investigations.",

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doi = "10.1016/j.msec.2008.07.029",

language = "English (US)",

volume = "29",

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journal = "Materials Science and Engineering C",

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T1 - Self-assembled amphiphilic polyhedral oligosilsesquioxane (POSS) grafted poly(vinyl alcohol) (PVA) nanoparticles

AU - Sheikh, Faheem A.

AU - Barakat, Nasser A.M.

AU - Kim, Byoung Suhk

AU - Aryal, Santosh

AU - Khil, Myung Seob

AU - Kim, Hak Yong

N1 - Funding Information: This work was supported by Korean Research Foundation Grant founded by Korean Government (MOEHRD) (The Center for Health Care Technology, Chonbuk National University, Jeonju 561-756 Republic of Korea). Author is thankful to Mr. Jong Bae Park of KBSI, Jeonju branch for utilizing his skill to do AFM investigations.

PY - 2009/4/30

Y1 - 2009/4/30

N2 - In the present study, spherical nanoparticles (NPs) containing polyhedral oligosilsesquioxane (POSS) as an inner hydrophobic core and poly(vinyl alcohol) PVA as a hydrophilic outer shell were prepared by dialysis approach. Preparation of amphiphilic POSS-grafted-PVA co-polymer was characterized by 1H NMR and FT-IR. The results indicated urethane linkage between monoisocyanate group of POSS macromer and the hydroxyl groups of PVA. The dynamic light scattering (DLS) and electrophoretic light scattering (ELS) of the NPs revealed that they have an average hydrodynamic diameter and negative zeta (ζ)-potential of 215 nm and - 161 mV, respectively. Atomic force microscopy (AFM) and bio-transmission electron microscope (BIO-TEM) have shown unagglomerated NPs within a diameter range of 60-90 nm. The prepared NPs were investigated to improve the control release of anticancer drug; paclitaxel as a model drug. Due to drug loading, the hydrodynamic diameter and negative zeta (ζ)-potential have changed to 325 nm and - 14 mV, respectively. In addition, in-vitro drug release experiments were conducted; the obtained results explicated continuous release for over 40 days. However, in case of using pure drug only, the drug completely released within 1 h.

AB - In the present study, spherical nanoparticles (NPs) containing polyhedral oligosilsesquioxane (POSS) as an inner hydrophobic core and poly(vinyl alcohol) PVA as a hydrophilic outer shell were prepared by dialysis approach. Preparation of amphiphilic POSS-grafted-PVA co-polymer was characterized by 1H NMR and FT-IR. The results indicated urethane linkage between monoisocyanate group of POSS macromer and the hydroxyl groups of PVA. The dynamic light scattering (DLS) and electrophoretic light scattering (ELS) of the NPs revealed that they have an average hydrodynamic diameter and negative zeta (ζ)-potential of 215 nm and - 161 mV, respectively. Atomic force microscopy (AFM) and bio-transmission electron microscope (BIO-TEM) have shown unagglomerated NPs within a diameter range of 60-90 nm. The prepared NPs were investigated to improve the control release of anticancer drug; paclitaxel as a model drug. Due to drug loading, the hydrodynamic diameter and negative zeta (ζ)-potential have changed to 325 nm and - 14 mV, respectively. In addition, in-vitro drug release experiments were conducted; the obtained results explicated continuous release for over 40 days. However, in case of using pure drug only, the drug completely released within 1 h.

KW - Amphiphilic

KW - Dialysis

KW - Drug release

KW - Nanoparticles

KW - Paclitaxel

KW - Self-assembly

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SN - 0928-4931

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Self-assembled amphiphilic polyhedral oligosilsesquioxane (POSS) grafted poly(vinyl alcohol) (PVA) nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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