@article{18549423de2841a9bd03ecf7ef2d359e,
title = "Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy",
abstract = "Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self-assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural killer (NK) cells by the oxidative metabolite of the selenopeptide is developed. With the advantages of the enzyme-induced size-reduction and the reactive-oxygen-species-driven deselenization, this selenopeptide is able to deliver therapeutics, e.g., doxorubicin (DOX), to solid tumors and further activate the NK cells in a programmed manner. Importantly, in vitro and in vivo results prove the mutual promotion between the DOX-induced chemotherapy and the selenopeptide-induced immunotherapy, which synergistically contribute to the improved antitumor efficacy. It is anticipated that the selenopeptide may provide a type of promising stimuli-responsive immune modulator for versatile biomedical applications.",
keywords = "chemoimmunotherapy, drug delivery, programmable nanomedicine, selenopeptide, self-assembly",
author = "Ziyu Wei and Yu Yi and Zhen Luo and Xiaoyun Gong and Yuxing Jiang and Dayong Hou and Li Zhang and Zimo Liu and Mandi Wang and Jie Wang and Ruochen Guo and Jinjun Yang and Lei Wang and Hao Wang and Yuliang Zhao",
note = "Funding Information: Z.W. and Y.Y. contributed equally to this work. This research was financially supported by the National Key R&D Program of China (No. 2018YFE0205400), the National Natural Science Foundation of China (Nos. 21805058, 51890892, and 22175048), and the Natural Science Foundation of Tianjin City (No. 20JCYBJC00580). The authors thank Prof. Huaping Xu (Tsinghua University), Prof. Yiye Li (NCNST), Prof. Zengying Qiao (NCNST), and Muhetaerjiang Mamuti (NCNST) for their helpful discussions. The authors also appreciate Prof. Yuanchen Dong and Yujie Li (Institute of Chemistry, Chinese Academy of Sciences) for their assistance in the TEM study, and Siyuan Tan (National Institute of Metrology) for his help in the MS analysis. Funding Information: Z.W. and Y.Y. contributed equally to this work. This research was financially supported by the National Key R&D Program of China (No. 2018YFE0205400), the National Natural Science Foundation of China (Nos. 21805058, 51890892, and 22175048), and the Natural Science Foundation of Tianjin City (No. 20JCYBJC00580). The authors thank Prof. Huaping Xu (Tsinghua University), Prof. Yiye Li (NCNST), Prof. Zengying Qiao (NCNST), and Muhetaerjiang Mamuti (NCNST) for their helpful discussions. The authors also appreciate Prof. Yuanchen Dong and Yujie Li (Institute of Chemistry, Chinese Academy of Sciences) for their assistance in the TEM study, and Siyuan Tan (National Institute of Metrology) for his help in the MS analysis. Note: The linked affiliation for author Jinjun Yang was corrected on April 27, 2022, after initial publication online. Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2022",
month = apr,
day = "27",
doi = "10.1002/adma.202108167",
language = "English (US)",
volume = "34",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley",
number = "17",
}