Selective targeting of gold nanorods at the mitochondria of cancer cells: Implications for cancer therapy

Liming Wang, Ying Liu, Wei Li, Xiumei Jiang, Yinglu Ji, Xiaochun Wu, Ligeng Xu, Yang Qiu, Kai Zhao, Taotao Wei, Yufeng Li, Yuliang Zhao, Chunying Chen

Research output: Contribution to journalArticlepeer-review

414 Scopus citations

Abstract

We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy.

Original languageEnglish (US)
Pages (from-to)772-780
Number of pages9
JournalNano Letters
Volume11
Issue number2
DOIs
StatePublished - Feb 9 2011

Keywords

  • Gold nanorods
  • intracellular localization
  • mitochondrion-targeted nanomaterials
  • serum proteins
  • tumor therapy
  • uptake and removal

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

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