Selective mitochondrial autophagy during erythroid maturation

Min Chen, Hector Sandoval, Jin Wang

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Accumulating evidence suggests that autophagy can be selective in the clearance of organelles in yeast and in mammalian cells. We have observed that the sequestration of mitochondria by autophagosomes was defective in reticulocytes in the absence of Nix. Nix is required for the dissipation of mitochondrial membrane potential (DeltaPsim) during erythroid maturation. Moreover, pharmacological agents that induce the loss of DeltaPsim can restore the sequestration of mitochondria by autophagosomes and promote mitochondrial clearance in Nix(-/-) erythroid cells. Our data suggest that mitochondrial depolarization induces recognition and sequestration of mitochondria by autophagosomes. Elucidating the mechanisms underlying selective mitochondrial autophagy not only will help us to understand the mechanisms for erythroid maturation, but also may provide insights into mitochondrial quality control by autophagy in the protection against aging, cancer and neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)926-8
Number of pages3
JournalAutophagy
Volume4
Issue number7
StatePublished - Oct 2008

Keywords

  • Anemia, Hemolytic
  • Animals
  • Autophagy
  • Erythropoiesis
  • Humans
  • Membrane Potential, Mitochondrial
  • Membrane Proteins
  • Mice
  • Mitochondria
  • Mitochondrial Proteins
  • Reticulocytes
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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