Selective functionalization of cantilever biosensors using a microarray spotter

Keith L. Aubin, Seung Min Park, Jose M. Moran-Mirabal, Bojan R. Ilic, Marianna Kondratovich, David M. Lin, Harold G. Craighead

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a novel method to selectively functionalize small groups of resonant NEMS cantilever based biosensors in an array of devices. This work presents a solution to the long standing problem of device functionalization where it is desirable to treat different subsets of devices on a single chip or array with different compounds. Using a microarray spotter, small volumes (spots) of an oligonucleotide solution were dispensed onto released devices with the intent to hybridize these small DNA strands and detect the additional bound mass through resonant frequency shift. Preliminary data suggests that additional mass selectively bound to the spotted devices.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages226-228
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • Biosensor
  • Cantilever
  • NEMS
  • Spotter

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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