Selective activators of thyroid hormone receptors

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

An excess of thyroid hormone (TH) leads to a mix of deleterious (increased heart rate, muscle wasting and osteoporosis) and beneficial effects (reduced serum cholesterol and lipoprotein A and weight loss). All of these actions are mediated by nuclear thyroid hormone receptors (TRs), however, genetic evidence suggests that different TR isoforms do not contribute equally to individual TH effects. Thus, TR isoform selective activators could mimic the beneficial aspects of TH excess while avoiding the harmful effects. This article reviews new selective TR activators, their mechanism of action (they work by targeting the TR-β isoform) and their actions in animal models. It is clear that these compounds represent a promising new avenue for the treatment of lipid disorders and obesity. 2004

Original languageEnglish (US)
Pages (from-to)489-500
Number of pages12
JournalExpert Opinion on Investigational Drugs
Volume13
Issue number5
DOIs
StatePublished - May 1 2004

Keywords

  • Cholesterol
  • Obesity
  • Selective modulation
  • Thyroid hormone

ASJC Scopus subject areas

  • Pharmacology

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