Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?

Szczepan M. Bilinski, Malgorzata Kloc, Waclaw Tworzydlo

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Early oocytes of nearly all animal species contain a transient organelle assemblage termed the Balbiani body. Structure and composition of this assemblage may vary even between closely related species. Despite this variability, the Balbiani body always comprises of numerous tightly clustered mitochondria and accumulations of nuage material. It has been suggested that the Balbiani body is an evolutionarily ancestral structure, which plays a role in various processes such as the localization of organelles and macromolecules to the germ plasm, lipidogenesis, as well as the selection/elimination of dysfunctional mitochondria from female germline cells. We suggest that the selection/elimination of mitochondria is a primary and evolutionarily ancestral function of Balbiani body, and that the other functions are secondary, evolutionarily derived additions. We propose a simple model explaining the role of the Balbiani body in the selection of mitochondria, i.e., in the mitochondrial DNA (mtDNA) bottleneck phenomenon.

Original languageEnglish (US)
Pages (from-to)1405-1412
Number of pages8
JournalJournal of Assisted Reproduction and Genetics
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2017

Keywords

  • Balbiani body
  • Mitochondrial network
  • Oocyte
  • Selection of mitochondria
  • mtDNA bottleneck

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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