To the Editor: We have recently treated three healthy adults who presented with generalized seizures shortly after jogging. Each person had previously been asymptomatic, and each had a normal neurologic examination after the seizure. In all three patients computed tomographic imaging revealed small frontal cortical lesions: an arteriovenous malformation, an astrocytoma, and a cyst. Their location is of interest, because injury to the frontal cortex, which includes the motor cortex, is more likely to cause seizures than injury to other cortical areas. The physiologic mechanism by which the seizures were provoked was probably hyperventilation induced by exercise and resulting in.
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