Segmentation, recognition and tracing analysis for high-content cell-cycle screening

Donggang Yu, Tuan D. Pham, Xiaobo Zhou, Stephen T. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

We present in this paper some new and efficient algorithms for segmentation, recognition and tracing analysis of cell phases for high-content screening. The conceptual frameworks are based on the morphological structures of cells where a series of morphological structural points are established. Furthermore, we address the issue of touching cells and then propose morphological techniques for cell separation, reconstruction and tracing analysis. The new segmentation method can resolve the question of over-segmentation. The tracing analysis of cell phases is based on cell shape, geometrical features and difference information of corresponding neighbor frames. Experiment results test the efficiency of the new method.

Original languageEnglish (US)
Title of host publicationComputational Models For Life Sciences (CMLS '07) - 2007 International Symposium
Pages66-75
Number of pages10
Volume952
DOIs
StatePublished - Dec 1 2007
Event2007 International Symposium on Computational Models for Life Sciences, CMLS '07 - Gold Coast, QLD, Australia
Duration: Dec 17 2007Dec 19 2007

Other

Other2007 International Symposium on Computational Models for Life Sciences, CMLS '07
CountryAustralia
CityGold Coast, QLD
Period12/17/0712/19/07

Keywords

  • Analysis of cell phases
  • High-content screening
  • Image contours
  • Image reconstruction
  • Morphological structures
  • Shape recognition

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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