TY - JOUR
T1 - Second malignant neoplasms in patients under 40 years of age with laryngeal cancer
AU - Albright, James
AU - Karpati, Ronit
AU - Topham, Allan K.
AU - Spiegel, Joseph R.
AU - Sataloff, Robert T.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Objectives/Hypothesis: To determine the incidence of second malignant neoplasms (SMN) in patients under 40 years of age with invasive squamous cell carcinoma (SCC) of the larynx. Study Design: Retrospective. Methods: Using a National Cancer Institute tumor registry database encompassing 1973-1996, the incidence of SMN in patients under 40 years of age with laryngeal cancer was determined and compared with that of the registry's older, more traditional laryngeal cancer population. Median follow-up was 136 months. Results: Among the 364 patients under the age of 40 years with laryngeal cancer, 30 (8.2%) had developed a secondary malignancy to date. In comparison, 4876 (21.4%) of 22,786 patients 40 years or older with laryngeal cancer were affected by an SMN. Kaplan-Meier analysis of the younger cohort projected 3.0%, 6.8%, and 10.7% relative risk of developing a SMN at any site over 5-, 10-, and 15-year periods, respectively, after index tumor diagnosis. Similar results for the older cohort were 14.2%, 28.1%, and 39.4% at 5, 10, and 15 years, respectively. Further Kaplan-Meier analysis demonstrated at least a fourfold increased risk for the development of secondary upper aerodigestive tract malignancies among older compared with younger patients. Conclusion: Pa under 40 years of age with invasive SCC of thetients larynx are significantly less likely to develop a second malignancy than their older counterparts.
AB - Objectives/Hypothesis: To determine the incidence of second malignant neoplasms (SMN) in patients under 40 years of age with invasive squamous cell carcinoma (SCC) of the larynx. Study Design: Retrospective. Methods: Using a National Cancer Institute tumor registry database encompassing 1973-1996, the incidence of SMN in patients under 40 years of age with laryngeal cancer was determined and compared with that of the registry's older, more traditional laryngeal cancer population. Median follow-up was 136 months. Results: Among the 364 patients under the age of 40 years with laryngeal cancer, 30 (8.2%) had developed a secondary malignancy to date. In comparison, 4876 (21.4%) of 22,786 patients 40 years or older with laryngeal cancer were affected by an SMN. Kaplan-Meier analysis of the younger cohort projected 3.0%, 6.8%, and 10.7% relative risk of developing a SMN at any site over 5-, 10-, and 15-year periods, respectively, after index tumor diagnosis. Similar results for the older cohort were 14.2%, 28.1%, and 39.4% at 5, 10, and 15 years, respectively. Further Kaplan-Meier analysis demonstrated at least a fourfold increased risk for the development of secondary upper aerodigestive tract malignancies among older compared with younger patients. Conclusion: Pa under 40 years of age with invasive SCC of thetients larynx are significantly less likely to develop a second malignancy than their older counterparts.
KW - Cancer in young patients
KW - Laryngeal carcinoma
KW - Second malignant neoplasms
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U2 - 10.1097/00005537-200104000-00002
DO - 10.1097/00005537-200104000-00002
M3 - Article
C2 - 11359120
AN - SCOPUS:0035068375
VL - 111
SP - 563
EP - 567
JO - The Laryngoscope
JF - The Laryngoscope
SN - 0023-852X
IS - 4 I
ER -