Second hand smoke stimulates tumor angiogenesis and growth

Bo Qing Zhu, Christopher Heeschen, Richard E. Sievers, Joel S. Karliner, William W. Parmley, Stanton A. Glantz, John P. Cooke

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Exposure to second hand smoke (SHS) is believed to cause lung cancer. Pathological angiogenesis is a requisite for tumor growth. Lewis lung cancer cells were injected subcutaneously into mice, which were then exposed to sidestream smoke (SHS) or clean room air and administered vehicle, cerivastatin, or mecamylamine. SHS significantly increased tumor size, weight, capillary density, VEGF and MCP-1 levels, and circulating endothelial progenitor cells (EPC). Cerivastatin (an inhibitor of HMG-coA reductase) or mecamylamine (an inhibitor of nicotinic acetylcholine receptors) suppressed the effect of SHS to increase tumor size and capillary density. Cerivastatin reduced MCP-1 levels, whereas mecamylamine reduced VEGF levels and EPC. These studies reveal that SHS promotes tumor angiogenesis and growth. These effects of SHS are associated with increases in plasma VEGF and MCP-1 levels, and EPC, mediated in part by isoprenylation and nicotinic acetylcholine receptors.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalCancer Cell
Volume4
Issue number3
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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