Seasonal invasive pneumococcal disease in children: Role of preceding respiratory viral infection

Krow Ampofo, Jeffrey Bender, Xiaoming Sheng, Kent Korgenski, Judy Daly, Andrew T. Pavia, Carrie L. Byington

Research output: Contribution to journalArticlepeer-review

138 Scopus citations


OBJECTIVE. Our objective was to demonstrate correlations between invasive pneumococcal disease in children and circulating respiratory viruses. METHODS.This retrospective study included 6 winter respiratory viral seasons (2001-2007) in Intermountain Healthcare, an integrated health system in the Intermountain West, including Primary Children's Medical Center in Salt Lake City, Utah. Children < 18 years of age who were hospitalized with either invasive pneumococcal disease in any Intermountain Healthcare facility or culture-confirmed invasive pneumococcal disease at Primary Children's Medical Center were included. We analyzed the correlation between invasive pneumococcal disease and circulating respiratory viruses. RESULTS.A total of 435 children with invasive pneumococcal disease and 203 with culture-confirmed invasive pneumococcal disease were hospitalized in an Inter-mountain Healthcare facility or Primary Children's Medical Center during the study period. During the same period, 6963 children with respiratory syncytial virus, 1860 with influenza virus, 1459 with parainfluenza virus, and 818 with adenoviruses were evaluated at Primary Children's Medical Center. A total of 253 children with human metapneumovirus were identified during the last 5 months of the study. There were correlations between invasive pneumococcal disease and seasonal respiratory syn-cytial virus, influenza virus, and human metapneumovirus activity. The correlation with invasive pneumococcal disease was strong up to 4 weeks after respiratory syncytial virus activity. For influenza virus and human metapneumovirus, the corelations were strong at 2 weeks after activity of these viruses. Pneumonia was the most common clinical disease associated with culture-confirmed invasive pneumo-coccal disease, mostly attributable to serotypes 1, 19A, 3, and 7F. CONCLUSIONS. In the post-pneumococcal conjugate vaccine era, seasonal increases in respiratory syncytial virus, influenza virus, and human metapneumovirus infections in children were associated with increased pediatric admissions with invasive pneumococcal disease, especially pneumonia caused by nonvaccine serotypes. Copyring

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
Issue number2
StatePublished - Aug 2008


  • Children
  • Invasive pneumococcal disease
  • Respiratory viral infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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