Sealing of polyester prostheses with autologous fibrin glue and bone marrow

Alain Cardon, Nabil Chakfé, Fabien Thaveau, Edith Gagnon, Olivier Hartung, Sylvie Aillet, Yvon Kerdiles, Yves Marie Dion, Jean Georges Kretz, Charles J. Doillon

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The purpose of this study was to develop a sealing technique for polyester prosthetic grafts able to promote healing and reduce intimal hyperplasia. The porcine experimental model was aortoiliac bypass with a 6-mm diameter knitted polyester prosthetic graft implanted for 14 and 90 days. Animals were divided into three groups according to sealing technique as follows: preclotting with blood (group I, n = 12), sealing with autologous fibrin glue (group II, n = 14), and sealing with autologous fibrin glue and bone marrow cells (group III, n = 16). Feasibility and quality of sealing were evaluated by scanning electron microscopy prior to implantation and by assessment of blood loss. After removal, prostheses were cut into three segments comprising the proximal anastomosis, midsection, and distal anastomosis. Pieces were fixed, embedded in paraffin, and serially sectioned for histologic study. Histological study focused on the degree of stenosis and hyperplasia of the neointima of each prosthesis. The results of this short-term study indicate that sealing of polyester vascular prosthetic grafts with autologous fibrin glue and bone marrow cells is effective in reducing intimal hyperplasia. However further study will be needed to assess long-term healing.

Original languageEnglish (US)
Pages (from-to)543-552
Number of pages10
JournalAnnals of Vascular Surgery
Issue number6
StatePublished - 2000

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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