Screening Children at Risk for Retinoblastoma

A panel of members of the American Association of Ophthalmic Oncologists and Pathologists (AAOOP) with support from the American Association for Pediatric Ophthalmology and Strabismus and the American Academy of Pediatrics (AAP) was convened. Consensus statement from the panel recommended dedicated ophthalmic screening for all children at risk for retinoblastoma above the population risk. Risk stratification including genetic testing and counseling serves as the basis for screening of children at elevated risk for development of retinoblastoma. Frequency of examinations is adjusted on the basis of expected risk for RB1 mutation. Examination schedules are stratified on the basis of high-, intermediate-, and low-risk children. Children at high risk for retinoblastoma require more frequent screening, which may preferentially be examinations under anesthesia.