Scleral Buckling Alone or in Combination with Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment Repair: A Meta-Analysis of 7,212 Eyes

Prem A.H. Nichani, Arjan S. Dhoot, Marko M. Popovic, Arshia Eshtiaghi, Andrew Mihalache, Aman P. Sayal, Hannah J. Yu, Charles C. Wykoff, Peter J. Kertes, Rajeev H. Muni

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: The efficacy and safety of scleral buckling (SB) versus combination SB and pars plana vitrectomy (SB + PPV) for rhegmatogenous retinal detachment (RRD) repair remains unclear. Methods: A systematic review and meta-analysis was conducted to identify comparative studies published from Jan 2000-Jun 2021 that reported on the efficacy and/or safety following SB and SB + PPV for RRD repair. Final best-corrected visual acuity (BCVA) represented the primary endpoint, while reattachment rates and ocular adverse events were secondary endpoints. A random-effects meta-analysis was performed, and 95% confidence intervals were calculated. Results: Across 18 studies, 3912 SB and 3300 SB + PPV eyes were included. Final BCVA was nonsignificantly different between SB and SB + PPV (20/38 vs. 20/66 Snellen; WMD = -0.11 LogMAR; 95% CI: [-0.29, 0.07]; p = 0.23). Primary reattachment rate was similar between procedures (p = 0.74); however, SB alone achieved a significantly higher final reattachment rate (97.40% vs. 93.86%; RR = 1.03; 95% CI: [1.00, 1.06]; p = 0.04). Compared to SB + PPV, SB alone had a significantly lower risk of postoperative macular edema (RR = 0.69; 95% CI: [0.47, 1.00]; p = 0.05) and cataract formation (RR = 0.34; 95% CI: [0.12, 0.96]; p = 0.04). The incidence of macular hole, epiretinal membrane, residual subretinal fluid, proliferative vitreoretinopathy, elevated intraocular pressure, and extraocular muscle dysfunction were similar between SB and SB + PPV. Conclusions: There was no significant difference in final BCVA between SB + PPV and SB alone in RRD. SB alone offers a slightly higher final reattachment rate along with a reduced risk of macular edema and cataract. Primary reattachment rate and the incidence of other complications were similar between the two procedures.

Original languageEnglish (US)
Pages (from-to)296-314
Number of pages19
Issue number4
StatePublished - Aug 1 2022


  • Meta-analysis
  • Pars plana vitrectomy
  • Retina
  • Rhegmatogenous retinal detachment
  • Scleral buckle
  • Vitrectomy/methods
  • Humans
  • Scleral Buckling/methods
  • Treatment Outcome
  • Macular Edema/etiology
  • Retrospective Studies
  • Cataract/complications
  • Retinal Detachment/diagnosis

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology


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