Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice

Vijayasree V. Giridharan, Rajarajan A. Thandavarayan, Hari N. Bhilwade, Kam M. Ko, Kenichi Watanabe, Tetsuya Konishi

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

This study aimed to investigate the potential beneficial effect of an antioxidant lignan, Schisandrin B (Sch B), against cisplatin (cDDP) induced oxidative stress mediated geno-and neuro-toxicities. A dose of 10 mg/kg cDDP induced considerable genotoxicity in mice, and Sch B treatment attenuated the cDDP-induced DNA damage as assessed by the comet assay in the brain. The frequency of micro-nucleated erythrocyte production in bone marrow was also significantly reduced by Sch B treatment in cDDP-treated mice. In neurobehavioral studies, Sch B significantly prevented the memory deficits induced by cDDP, and had an anxiolytic effect in the elevated plus maze task. Sch B treatment significantly attenuated lipid peroxidation, acetylcholinesterase activity and nitrite levels induced by cDDP. Furthermore, Sch B effectively inhibited NF-κB and p53 activation, and cleaved caspase-3 expression in cDDP-treated mice. Hence, Sch B with potent antioxidant and neuro-protective property with no mutagenic activity would be beneficial complementary food factor against cDDP induced oxidative stress.

Original languageEnglish (US)
Pages (from-to)50-60
Number of pages11
JournalFree Radical Research
Volume46
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Cisplatin
  • Comet assay
  • Genotoxicity
  • Micronucleus assay
  • Neurotoxicity
  • Schisandrin B

ASJC Scopus subject areas

  • Biochemistry

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