Saturated Alanine Scanning Mutagenesis of the Pneumococcus Competence Stimulating Peptide Identifies Analogs That Inhibit Genetic Transformation

Medicine & Life Sciences

• Genetic Transformation 100%
• Streptococcus pneumoniae 65%
• Alanine 65%
• Mutagenesis 63%
• Mental Competency 61%
• Glutamic Acid 56%
• Microbial Drug Resistance 51%
• Peptides 41%
• Horizontal Gene Transfer 34%
• Genes 20%
• Amino Acids 18%
• Pheromones 17%
• Regulon 16%
• Modern 1601-history 15%
• Hydrophobic and Hydrophilic Interactions 14%
• Amino Acid Substitution 13%
• Aptitude 8%
• Bacteria 8%

Agriculture & Biology

• genetic transformation 70%
• mutagenesis 61%
• glutamates 60%
• alanine 59%
• Streptococcus pneumoniae 48%
• antibiotic resistance genes 47%
• peptides 43%
• horizontal gene transfer 29%
• regulon 15%
• amino acids 14%
• amino acid substitution 13%
• gene transfer 13%
• hydrophobicity 13%
• antibiotic resistance 12%
• pheromones 12%
• acidity 11%
• medicine 11%
• receptors 8%
• bacteria 7%

Chemistry

• Glutamate Residue 90%
• Alanine 61%
• Antimicrobial Agent 44%
• Chemical Transformation 40%
• Resistance 40%
• Peptide 37%
• Peptide Pheromone 31%
• Substitution Reaction 30%
• Acid 16%
• Hydrophobicity 13%
• Enantiomer 12%