Abstract
To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free voluntary post-antibody testing against the spike protein IgG for all fully vaccinated employees. Post-vaccination response against SARS-CoV-2 was assessed using the FDA-EUA approved VITROS anti-SARS-CoV-2 IgG immunometric assay specific to the spike protein. Out of a total of 3266 antibody tests performed in fully vaccinated Texas Children's, 99.4% had a positive antibody response to the spike protein. From the 21 employees (0.6%) that had a negative response, 66.7% reported taking immunosuppressive drugs and/or biologics. Our data shows that most of the employees tested at our institution mounted an immune response to the immunogen in the vaccine. Post-vaccination antibody testing against SARS-CoV-2 can provide useful information to guide decisions about future vaccine doses.
Original language | English (US) |
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Article number | e00261 |
Journal | Practical Laboratory Medicine |
Volume | 28 |
DOIs | |
State | Published - Jan 2022 |
Keywords
- Antibody
- COVID
- Employee
- SARS-CoV-2
- Serology
- Vaccine
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Clinical Biochemistry