@article{b36a29c0354e45bd90c19db63708aff7,
title = "SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)",
abstract = "The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individuals to receive either immediate or deferred vaccination, with one or two doses of mRNA SARS-CoV-2 vaccines. We measured binding and neutralizing antibodies against SARS-CoV-2 at enrollment and longitudinally. Median (IQR) time from SARS-CoV-2 infection to first vaccination was 68 (53-75) days in the immediate group, and 151 (137-173) days in the deferred group. At week 48, timing or number of vaccine doses did not influence the change in antibody levels relative to baseline. Adherence to the assigned vaccine regimen was lower in the deferred group, particularly in participants receiving two doses. Although the study ultimately lacked adequate power to draw firm conclusions, these results suggest possible benefits of prompt vaccination after recovery from COVID-19.",
author = "{ACTIV-3/VATICO study group and the STRIVE Network} and Sof{\'i}a S{\'a}bato and Susana Benet and Rogers, {Angela J.} and Murray, {Thomas A.} and Melissa Skeans and Beatriz Mothe and Roger Paredes and Ahmad Mourad and Francis Kiweewa and Dena Kamel and Jain, {Mamta K.} and Joseph Lutaakome and Nalubega, {Mary Grace} and Nicholus Sebudde and Eleftherios Mylonakis and Braun, {Dominique L.} and Timothy Hatlen and Ivan Kimuli and Cissy Kitko and Henry Mugerwa and Jonathan Kitonsa and Kami Kim and Tien, {Phyllis C.} and Jeroen Highbarger and McCormack, {Ashley L.} and Adriana Sanchez and Murray, {Daniel D.} and Babiker, {Abdel G.} and Davey, {Victoria J.} and Files, {D. Clark} and Gelijns, {Annetine C.} and Higgs, {Elizabeth S.} and Kan, {Virginia L.} and Matthews, {Gail V.} and Pett, {Sarah L.} and Lane, {H. Clifford} and Cavan Reilly and Goodman, {Anna L.} and Lundgren, {Jens D.} and Jos{\'e} Molt{\'o}",
note = "Publisher Copyright: {\textcopyright} 2025. The Author(s).",
year = "2025",
month = mar,
day = "22",
doi = "10.1038/s41598-025-92742-x",
language = "English (US)",
volume = "15",
pages = "9882",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}