SARS-CoV-2 Antibody Responses to the Ancestral SARS-CoV-2 Strain and Omicron BA.1 and BA.4/BA.5 Variants in Nursing Home Residents After Receipt of Bivalent COVID-19 Vaccine — Ohio and Rhode Island, September–November 2022

David H. Canaday, Oladayo A. Oyebanji, Elizabeth M. White, Jürgen Bosch, Clare Nugent, Igor Vishnepolskiy, Yasin Abul, Elise M. Didion, Alexandra Paxitzis, Nicholas Sundheimer, Vaishnavi Ragavapuram, Dennis Wilk, Debbie Keresztesy, Yi Cao, Kerri St Denis, Kevin W. McConeghy, L. Clifford McDonald, John A. Jernigan, Eleftherios Mylonakis, Brigid M. WilsonChristopher L. King, Alejandro B. Balazs, Stefan Gravenstein

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

What is already known about this topic? Previous COVID-19 monovalent vaccines provided substantial reductions in COVID-19–associated morbidity and mortality among nursing home residents; however, only one half of these residents and one quarter of nursing home staff members have received the COVID-19 bivalent booster dose to date. What is added by this report? Among nursing home residents in two states, SARS-CoV-2 antibody levels waned within months after vaccination, irrespective of previous SARS-CoV-2 infection, after monovalent booster vaccination. Antibody response broadened after the COVID-19 bivalent booster for vaccinated nursing home residents among those with and without previous infection. What are the implications for public health practice? All eligible nursing home residents and staff members should follow current recommendations to receive a bivalent COVID-19 booster dose to reduce their risk for SARS-CoV-2 infection, severe COVID-19–associated illness, and death.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalMorbidity and Mortality Weekly Report
Volume72
Issue number4
DOIs
StatePublished - Jan 27 2023

Keywords

  • Adult
  • Humans
  • COVID-19/epidemiology
  • SARS-CoV-2
  • COVID-19 Vaccines
  • Vaccines, Combined
  • Rhode Island
  • Antibody Formation
  • Ohio
  • Antibodies, Viral
  • Nursing Homes
  • Antibodies, Neutralizing

ASJC Scopus subject areas

  • Health(social science)
  • Health Information Management
  • Health, Toxicology and Mutagenesis
  • Epidemiology

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