Sarcomatoid chromophobe renal cell carcinoma with heterologous sarcomatoid elements: A case report and review of the literature

Gabriela Quiroga-Garza, Hema Khurana, Steven Shen, Alberto Ayala, Jae Ro

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Chromophobe renal cell carcinoma (CRCC) is a distinct subtype of renal cell carcinoma (RCC) that is well known for its relatively good prognosis. Sarcomatoid transformation in this tumor, although rare, has been well documented in the literature and, as in other types of RCC, carries an ominous prognosis for the patient. The finding of heterologous elements in the sarcomatoid component of CRCC is an extraordinary event, which has been reported in only 2 previous cases. Here, we present the third such case, occurring in the left kidney of a previously healthy 63-year-old woman. The nephrectomy specimen showed CRCC with extensive sarcomatoid changes displaying heterologous elements in the form of chondrosarcomatous and osteosarcomatous differentiation. As in other sarcomatoid RCCs, this tumor behaves aggressively, with frequent distant metastases. It is important to recognize the sarcomatoid component in these tumors because of its consequential adverse prognosis for the patient.

Original languageEnglish (US)
Pages (from-to)1857-1860
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume133
Issue number11
StatePublished - Nov 1 2009

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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