Sarcomatoid carcinoma of the prostate a clinicopathologic study of 12 patients

Rhonda L. Shannon, Jae Y. Ro, David J. Grignon, Nelson G. Ordóñez, Douglas E. Johnson, Bruce Mackay, Bernard Tětu, Alberto G. Ayala

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Sarcomatoid carcinoma of the prostate is a rare tumor that can be difficult to distinguish from a true sarcoma. The authors report 12 patients in whom the typical light microscopic appearance of prostatic adenocarcinoma was accompanied by the appearance of spindled or pleomorphic sarcomatoid areas within the same specimen or in subsequent accessions. Immunostaining or electron microscopic study demonstrated epithelial differentiation within the sarcomatoid area(s) in 6 of the 11 patients in whom special studies were performed. All nine patients for whom follow-up data were available died of disease within 3 to 48 months (median time until death, 12.0 months) after the appearance of the sarcomatoid carcinoma, and the clinical course in each instance was characterized by aggressive local recurrence. Our experience confirms that sarcomatoid carcinoma of the prostate is an aggressive variant of prostatic adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)2676-2682
Number of pages7
Issue number11
StatePublished - Jun 1 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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