TY - GEN
T1 - Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery
AU - Kam, Anthony W.
AU - Wang, Honghui
AU - Farahani, Keyvan
AU - Thomasson, David
AU - O'Neill, Brian
AU - Angstadt, Mary
AU - Jesson, Johnny
AU - Li, King C.P.
PY - 2007
Y1 - 2007
N2 - For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.
AB - For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.
KW - Drug and gene delivery
KW - MR thermometry
KW - Pulsed high intensity focused ultrasound
KW - Safety
UR - https://www.scopus.com/pages/publications/34548767619
UR - https://www.scopus.com/inward/citedby.url?scp=34548767619&partnerID=8YFLogxK
U2 - 10.1063/1.2744313
DO - 10.1063/1.2744313
M3 - Conference contribution
AN - SCOPUS:34548767619
SN - 0735404194
SN - 9780735404199
T3 - AIP Conference Proceedings
SP - 455
EP - 461
BT - 6th International Symposium on Therapeutic Ultrasound
T2 - 6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND
Y2 - 30 August 2007 through 2 September 2007
ER -