Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery

Anthony W. Kam; Honghui Wang; Keyvan Farahani; David Thomasson; Brian O'Neill; Mary Angstadt; Johnny Jesson; King C.P. Li

doi:10.1063/1.2744313

Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery

Anthony W. Kam, Honghui Wang, Keyvan Farahani, David Thomasson, Brian O'Neill, Mary Angstadt, Johnny Jesson, King C.P. Li

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.

Original language	English (US)
Title of host publication	6th International Symposium on Therapeutic Ultrasound
Pages	455-461
Number of pages	7
Volume	911
DOIs	https://doi.org/10.1063/1.2744313
State	Published - Sep 24 2007
Event	6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND - Oxford, United Kingdom Duration: Aug 30 2007 → Sep 2 2007

Other

Other	6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND
Country/Territory	United Kingdom
City	Oxford
Period	8/30/07 → 9/2/07

Keywords

Drug and gene delivery
MR thermometry
Pulsed high intensity focused ultrasound
Safety

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.2744313

Cite this

Kam, AW, Wang, H, Farahani, K, Thomasson, D, O'Neill, B, Angstadt, M, Jesson, J & Li, KCP 2007, Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery. in 6th International Symposium on Therapeutic Ultrasound. vol. 911, pp. 455-461, 6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, Oxford, United Kingdom, 8/30/07. https://doi.org/10.1063/1.2744313

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abstract = "For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.",

keywords = "Drug and gene delivery, MR thermometry, Pulsed high intensity focused ultrasound, Safety",

author = "Kam, {Anthony W.} and Honghui Wang and Keyvan Farahani and David Thomasson and Brian O'Neill and Mary Angstadt and Johnny Jesson and Li, {King C.P.}",

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AU - Kam, Anthony W.

AU - Wang, Honghui

AU - Farahani, Keyvan

AU - Thomasson, David

AU - O'Neill, Brian

AU - Angstadt, Mary

AU - Jesson, Johnny

AU - Li, King C.P.

PY - 2007/9/24

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N2 - For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.

AB - For a limited range of exposure parameters, pulsed high intensity focused ultrasound (HIFU) has been shown to increase the delivery of certain systemically administered macromolecular diagnostic and therapeutic agents in mice. The mechanism for the enhanced delivery has not been demonstrated definitively and, in principle, can include thermal, cavitational, and non-cavitation mechanical effects. The sonicated tissue has no damage on histology. As a step towards clinical translation, the safety of this technique needs to be assessed in a clinically relevant manner. In this study, the safety of pulsed HIFU is evaluated with near real-time phase shift magnetic resonance (MR) thermometry and anatomic MR imaging using rabbits as subjects. MR guidance enables pulsed HIFU enhanced delivery to be implemented safely from a thermal standpoint. Although the effects of pulsed HIFU are not seen on anatomic MR images, they may be detected on MR sequences sensitive to permeability, diffusion, and elasticity. Such work that may optimize pulsed HIFU enhanced delivery is in progress.

KW - Drug and gene delivery

KW - MR thermometry

KW - Pulsed high intensity focused ultrasound

KW - Safety

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ER -

Safety of pulsed high intensity focused ultrasound for enhanced drug and gene delivery

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