TY - JOUR
T1 - Safety Assessment of Nanomaterials to Eyes
T2 - An Important but Neglected Issue
AU - Zhu, Shuang
AU - Gong, Linji
AU - Li, Yijian
AU - Xu, Haiwei
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
This work was supported by the National Basic Research Program of China (Grant Nos. 2016YFA0201600 and 2018YFA0107302), National Natural Science Foundation of China (Grant Nos. 551822207, 51772292, 31571015, 11621505, and 11435002), Key Research Program of Frontier Sciences (Grant No. QYZDJ-SSW-SLH022), Youth Innovation Promotion Association CAS (Grant No. 2013007), and the Foundation of Southwest Hospital (Grant Nos. SWH2017ZDCX2007 and SWH2016LHJC-07).
Publisher Copyright:
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/8
Y1 - 2019/8
N2 - The production and application of nanomaterials have grown tremendously during last few decades. The widespread exposure of nanoparticles to the public is provoking great concerns regarding their toxicity to the human body. However, in comparison with the extensive studies carried out to examine nanoparticle toxicity to the human body/organs, one especially vulnerable organ, the eye, is always neglected. Although it is a small part of the body, 90% of outside information is obtained via the ocular system. In addition, eyes usually directly interact with the surrounding environment, which may get severer damage from toxic nanoparticles compared to inner organs. Therefore, the study of assessing the potential nanoparticle toxicity to the eyes is of great importance. Here, the recent advance of some representative manufactured nanomaterials on ocular toxicity is summarized. First, a brief introduction of ocular anatomy and disorders related to particulate matter exposure is presented. Following, the factors that may influence toxicity of nanoparticles to the eye are emphasized. Next, the studies of representative manufactured nanoparticles on eye toxicity are summarized and classified. Finally, the limitations that are associated with current nanoparticle-eye toxicity research are proposed.
AB - The production and application of nanomaterials have grown tremendously during last few decades. The widespread exposure of nanoparticles to the public is provoking great concerns regarding their toxicity to the human body. However, in comparison with the extensive studies carried out to examine nanoparticle toxicity to the human body/organs, one especially vulnerable organ, the eye, is always neglected. Although it is a small part of the body, 90% of outside information is obtained via the ocular system. In addition, eyes usually directly interact with the surrounding environment, which may get severer damage from toxic nanoparticles compared to inner organs. Therefore, the study of assessing the potential nanoparticle toxicity to the eyes is of great importance. Here, the recent advance of some representative manufactured nanomaterials on ocular toxicity is summarized. First, a brief introduction of ocular anatomy and disorders related to particulate matter exposure is presented. Following, the factors that may influence toxicity of nanoparticles to the eye are emphasized. Next, the studies of representative manufactured nanoparticles on eye toxicity are summarized and classified. Finally, the limitations that are associated with current nanoparticle-eye toxicity research are proposed.
KW - eyes
KW - nanomaterials
KW - nanosafety
KW - ocular damage
KW - toxicity
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U2 - 10.1002/advs.201802289
DO - 10.1002/advs.201802289
M3 - Review article
AN - SCOPUS:85067788103
SN - 2198-3844
VL - 6
JO - Advanced Science
JF - Advanced Science
IS - 16
M1 - 1802289
ER -