TY - JOUR
T1 - S100P as a Marker for Urothelial Histogenesis
T2 - A Critical Review and Comparison With Novel and Traditional Urothelial Immunohistochemical Markers
AU - Suryavanshi, Moushumi
AU - Sanz-Ortega, Julian
AU - Sirohi, Deepika
AU - Divatia, Mukul K
AU - Ohe, Chisato
AU - Zampini, Claudia
AU - Luthringer, Daniel J.
AU - Smith, Steven C.
AU - Amin, Mahul B.
PY - 2017/5
Y1 - 2017/5
N2 - S100P, or placental S100, is a member of a large family of S100 proteins and considered to be a promising immunohistochemical marker to support urothelial differentiation. This review synthesizes published data regarding the expression of S100P in urothelial carcinoma across histological grade and variant patterns, and in other malignancies, in an effort to summarize the state of understanding of this marker and evaluate its potential. We provide also a broad comparison of S100P with other contemporary and traditional urothelial markers and outline the potential utility of S100P in various diagnostically challenging scenarios. Taken in context, we recommend that to provide immunohistochemical support for consideration of urothelial differentiation, S100P may be included in a panel of markers (due to its high sensitivity), with better established (GATA3) and more specific (uroplakin 2) markers, for comparison with corresponding markers of other primary sites under consideration, depending on the clinical context. We emphasize that the overall most appropriate panel for any given case depends on the differential diagnosis engendered by the morphology encountered, and the constellation of clinical findings. As always with immunohistochemical panels, expected positive and negative markers for each diagnostic consideration should be included. Finally, since as of date there are no optimally sensitive or specific markers of urothelial differentiation, all final diagnoses relying on immunohistochemical support should be made in the appropriate clinical and histological context.
AB - S100P, or placental S100, is a member of a large family of S100 proteins and considered to be a promising immunohistochemical marker to support urothelial differentiation. This review synthesizes published data regarding the expression of S100P in urothelial carcinoma across histological grade and variant patterns, and in other malignancies, in an effort to summarize the state of understanding of this marker and evaluate its potential. We provide also a broad comparison of S100P with other contemporary and traditional urothelial markers and outline the potential utility of S100P in various diagnostically challenging scenarios. Taken in context, we recommend that to provide immunohistochemical support for consideration of urothelial differentiation, S100P may be included in a panel of markers (due to its high sensitivity), with better established (GATA3) and more specific (uroplakin 2) markers, for comparison with corresponding markers of other primary sites under consideration, depending on the clinical context. We emphasize that the overall most appropriate panel for any given case depends on the differential diagnosis engendered by the morphology encountered, and the constellation of clinical findings. As always with immunohistochemical panels, expected positive and negative markers for each diagnostic consideration should be included. Finally, since as of date there are no optimally sensitive or specific markers of urothelial differentiation, all final diagnoses relying on immunohistochemical support should be made in the appropriate clinical and histological context.
KW - Biomarkers, Tumor
KW - Carcinoma, Transitional Cell
KW - Humans
KW - Immunohistochemistry
KW - Urinary Bladder Neoplasms
KW - Urologic Neoplasms
KW - Urothelium
KW - Journal Article
KW - Review
U2 - 10.1097/PAP.0000000000000150
DO - 10.1097/PAP.0000000000000150
M3 - Article
C2 - 28398953
SN - 1072-4109
VL - 24
SP - 151
EP - 160
JO - Advances in Anatomic Pathology
JF - Advances in Anatomic Pathology
IS - 3
ER -