rpoB gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China

Xin Ma; Haiying Wang; Yunfeng Deng; Zhimin Liu; Yong Xu; Xi Pan; James M. Musser; Edward A. Graviss

doi:10.1128/JCM.00515-06

rpoB gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China

Xin Ma, Haiying Wang, Yunfeng Deng, Zhimin Liu, Yong Xu, Xi Pan, James M. Musser, Edward A. Graviss

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.

Original language	English (US)
Pages (from-to)	3409-3412
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	44
Issue number	9
DOIs	https://doi.org/10.1128/JCM.00515-06
State	Published - Sep 2006

ASJC Scopus subject areas

Microbiology (medical)

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title = "rpoB gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China",

abstract = "Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.",

author = "Xin Ma and Haiying Wang and Yunfeng Deng and Zhimin Liu and Yong Xu and Xi Pan and Musser, \{James M.\} and Graviss, \{Edward A.\}",

year = "2006",

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language = "English (US)",

volume = "44",

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T1 - rpoB gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China

AU - Ma, Xin

AU - Wang, Haiying

AU - Deng, Yunfeng

AU - Liu, Zhimin

AU - Xu, Yong

AU - Pan, Xi

AU - Musser, James M.

AU - Graviss, Edward A.

PY - 2006/9

Y1 - 2006/9

N2 - Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.

AB - Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.

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JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 9

ER -

rpoB gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China

Abstract

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