rpoB gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China

Xin Ma, Haiying Wang, Yunfeng Deng, Zhimin Liu, Yong Xu, Xi Pan, James M. Musser, Edward A. Graviss

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.

Original languageEnglish (US)
Pages (from-to)3409-3412
Number of pages4
JournalJournal of Clinical Microbiology
Volume44
Issue number9
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Microbiology (medical)

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