@inbook{98259fd55a6e4f15a11af6c55b1b39c2,
title = "Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer",
abstract = "Inhibitor of growth family member 4 (ING4) is best known as a tumor suppressor that is frequently downregulated, deleted, or mutated in many cancers. ING4 regulates a broad array of tumor-related processes including proliferation, apoptosis, migration, autophagy, invasion, angiogenesis, DNA repair and chromatin remodeling. ING4 alters local chromatin structure by functioning as an epigenetic reader of H3K4 trimethylation histone marks (H3K4Me3) and regulating gene transcription through directing histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes. ING4 may serve as a useful prognostic biomarker for many cancer types and help guide treatment decisions. This review provides an overview of ING4{\textquoteright}s central functions in gene expression and summarizes current literature on the role of ING4 in cancer and its possible use in therapy.",
keywords = "Biomarker, Cancer, Chromatin remodeling, Epigenetics, Gene regulation, ING4, Tumor suppressor",
author = "Aymen Shatnawi and {Abu Rabe}, {Dina I.} and Frigo, {Daniel E.}",
note = "Funding Information: We want to thank Dr. Travis Salisbury (Marshall University, The Joan C. Edwards School of Medicine, WV) for reading the manuscript and provide constructive comments. Support for Dr. Shatnawi's laboratory was provided by WV-INBRE grant (P20GM103434). Authors declare that they have no conflict of interest, financial or otherwise, regarding the manuscript's content. Funding Information: We want to thank Dr. Travis Salisbury (Marshall University, The Joan C. Edwards School of Medicine, WV) for reading the manuscript and provide constructive comments. Support for Dr. Shatnawi's laboratory was provided by WV-INBRE grant (P20GM103434). Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = jan,
doi = "10.1016/bs.acr.2021.05.004",
language = "English (US)",
isbn = "9780128241257",
series = "Advances in Cancer Research",
publisher = "Academic Press",
pages = "225--262",
editor = "Tew, {Kenneth D.} and Fisher, {Paul B.}",
booktitle = "Advances in Cancer Research",
address = "United States",
}