Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer

Aymen Shatnawi, Dina I. Abu Rabe, Daniel E. Frigo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inhibitor of growth family member 4 (ING4) is best known as a tumor suppressor that is frequently downregulated, deleted, or mutated in many cancers. ING4 regulates a broad array of tumor-related processes including proliferation, apoptosis, migration, autophagy, invasion, angiogenesis, DNA repair and chromatin remodeling. ING4 alters local chromatin structure by functioning as an epigenetic reader of H3K4 trimethylation histone marks (H3K4Me3) and regulating gene transcription through directing histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes. ING4 may serve as a useful prognostic biomarker for many cancer types and help guide treatment decisions. This review provides an overview of ING4’s central functions in gene expression and summarizes current literature on the role of ING4 in cancer and its possible use in therapy.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
EditorsKenneth D. Tew, Paul B. Fisher
PublisherAcademic Press
Pages225-262
Number of pages38
ISBN (Print)9780128241257
DOIs
StatePublished - Jan 2021

Publication series

NameAdvances in Cancer Research
Volume152
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

Keywords

  • Biomarker
  • Cancer
  • Chromatin remodeling
  • Epigenetics
  • Gene regulation
  • ING4
  • Tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer'. Together they form a unique fingerprint.

Cite this