Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease

Akshay Shetty, Jennifer W. Hsu, Paul P. Manka, Wing Kin Syn

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized nations and is strongly associated with the metabolic syndrome. The prevalence of NAFLD continues to rise along with the epidemic of the metabolic syndrome. Metabolic homeostasis is linked to the circadian clock (rhythm), with multiple signaling pathways in organs regulated by circadian clock genes, and recent studies of circadian clock gene functions suggest that disruption of the circadian rhythm is associated with significant morbidity and mortality, including the metabolic syndrome. In the industrialized world, various human behaviors and activities such as work and eating patterns, jet lag, and sleep deprivation interfere with the circadian rhythm, leading to perturbations in metabolism and development of the metabolic syndrome. In this review, we discuss how disruption of the circadian rhythm is associated with various metabolic conditions that comprise the metabolic syndrome and NAFLD.

Original languageEnglish (US)
Pages (from-to)3187-3206
Number of pages20
JournalDigestive Diseases and Sciences
Volume63
Issue number12
DOIs
StatePublished - Dec 1 2018

Keywords

  • Circadian rhythm
  • Diabetes mellitus
  • Fatty liver
  • Nonalcoholic steatohepatitis
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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