Role of tacrolimus in the evolution of liver transplantation

Ronald W. Busuttil, John R. Lake

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Once regarded as a last-resort therapy for patients with end-stage liver disease, liver transplantation has become a viable therapeutic option because of sweeping improvements in surgical techniques and the development of more powerful immunosuppressive agents. The addition of tacrolimus to the immunosuppression regimen represents a highly potent therapy and a powerful defense against acute rejection. In the decade since tacrolimus was approved for use in the United States, it has become a widely used immunosuppressant in the field of liver transplantation.

Original languageEnglish (US)
Pages (from-to)S44-S51
Issue number9
StatePublished - May 15 2004

ASJC Scopus subject areas

  • Transplantation


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